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Article

Structural basis for recruitment of RILP by small GTPase Rab7.

The EMBO journal - 20 Apr 2005

Wu Mousheng, Wang Tuanlao, Loh Eva, Hong Wanjin, Song Haiwei

Abstract excerpt

Rab7 regulates vesicle traffic from early to late endosomes, and from late endosomes to lysosomes. The crystal structure of Rab7-GTP in complex with the Rab7 binding domain of RILP reveals that Rab7 interacts with RILP specifically via two distinct areas, with the first one involving the switch and interswitch regions and the second one consisting of RabSF1 and RabSF4. Disruption of these interactions by...

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Share to Dimerization
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Structure, Quaternary

Share to rab GTP-Binding Proteins

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Source

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Identifiers

PMID: 15933719
DOI: 10.1038/sj.emboj.7600643
PMCID: PMC1142575

Genes

RILP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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