Article

Differential Genotypic Effects of HSV-1 Infection on Cognitive Function and Pathology in the 5xFAD Mouse Model

2026-07-23

Abstract excerpt

Alzheimer’s disease (AD) involves several different etiopathogenic mechanisms. A recent infectious theory proposed that pathogens, such as HSV-1, could be the root cause of AD. In this study, we investigated HSV-1 infection in an animal model to test this infectious theory. Heterozygous 5XFAD mice (Het) carrying 5 AD-linked mutations on a C57BL/6 background and wild-type littermates (WT), were infected with HSV-1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6b0d514-0d94-533d-aea6-81b33d280051
DOI: 10.20944/preprints202607.1724.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential Genotypic Effects of HSV-1 Infection on Cognitive Function and Pathology in the 5xFAD Mouse ModelDOI 10.20944/preprints202607.1724.v1Read

Persistent Infection with Herpes Simplex Virus 1 and Alzheimer’s Disease—A Call to Study How Variability in Both Virus and Host may Impact DiseaseSemantic proximity Read

Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s DiseaseSemantic proximity Read

Alzheimer’s disease-associated β-Amyloid does not protect against Herpes Simplex Virus 1 brain infectionSemantic proximity Read

Herpes simplex virus type 1 and Alzheimerâ€™s disease: increasing evidence for a major role of the virusSemantic proximity Read

Asymptomatic neonatal herpes simplex virus infection in mice leads to long-term cognitive impairmentSemantic proximity Read

HSV-1 Infection Alters <i>MAPT</i> Splicing and Promotes Tau Pathology in Neural Models of Alzheimer’s DiseaseSemantic proximity Read

Viral Infection Induces Alzheimer’s Disease-Related Pathways and Senescence in iPSC-Derived Neuronal ModelsSemantic proximity Read

The association of herpes simplex virus and Alzheimer's disease: a potential synthesis of genetic and environmental factors.Semantic proximity Read

Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trialSemantic proximity Read

Characterization of effects of a neurotropic murine coronavirus infection on Alzheimer’s disease neuropathology of 5xFAD miceSemantic proximity Read

HSV-1 in brain and risk of Alzheimer's diseaseSemantic proximity Read

Insights into the pathogenesis of herpes simplex encephalitis from mouse models.Semantic proximity Read