Article

Characterization of effects of a neurotropic murine coronavirus infection on Alzheimer’s disease neuropathology of 5xFAD mice

2026-02-25

Abstract excerpt

<h4>Background</h4> Recent studies revealed key immunological mechanisms within the central nervous system (CNS) that contribute to Alzheimer’s disease pathology. Additionally, analyses of human AD datasets have also associated viral encephalitis exposure (i.e., viral-induced neuroinflammation) with the development of AD and dementia, highlighting the need to better understand how viral encephalitis and neuroimmu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c7c0a78f-af45-5c7d-8bca-e7608306e44d
DOI: 10.64898/2026.02.23.707587

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterization of effects of a neurotropic murine coronavirus infection on Alzheimer’s disease neuropathology of 5xFAD miceDOI 10.64898/2026.02.23.707587Read

Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer’s disease neuropathology yet induces wide-spread changes in gene expression across diverse cell typesSemantic proximity Read

Accelerated amyloid deposition in SARS-CoV-2 infected mouse models of Alzheimer’s diseaseSemantic proximity Read

Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimer’s DiseaseSemantic proximity Read

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease.Semantic proximity Read

Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infectionSemantic proximity Read

SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease riskSemantic proximity Read

Accelerated amyloid neurodegeneration in HIV-1-infected APP-KI Alzheimer’s disease miceSemantic proximity Read

Apolipoprotein E governs neuroinflammation resolution and recovery from viral encephalitisSemantic proximity Read

Single-Cell RNA Sequencing Transcriptomics Revealed HCMV IE2-Related Microglia Responses in Alzheimer’s-Like Disease in Transgenic MiceSemantic proximity Read

Systemic inflammation causes microglial dysfunction with a mixed AD-like pathologySemantic proximity Read

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s diseaseSemantic proximity Read

Modulation of C5a-C5aR1 signaling alters the dynamics of AD progressionSemantic proximity Read