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Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial

18 Jan 2025

Abstract excerpt

In vitro and animal studies have suggested that inoculation with herpes simplex virus 1 (HSV-1) can lead to amyloid deposits, hyperphosphorylation of tau, and/or neuronal loss. Here, we studied the association between HSV-1 and Alzheimer's disease biomarkers in humans. Our sample included 182 participants at risk of cognitive decline from the Multidomain Alzheimer Preventive Trial who had HSV-1 plasma serology...

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PMID: 39825066
DOI: 10.1038/s41598-024-84583-x

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