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Article

Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s Disease

6 Mar 2018

Abstract excerpt

This review focuses on research in the areas of epidemiology, neuropathology, molecular biology, and genetics that implicates herpes simplex virus type 1 (HSV-1) as a causative agent in the pathogenesis of sporadic Alzheimer’s disease (AD). Molecular mechanisms whereby HSV-1 induces AD-related pathophysiology and pathology, including neuronal production and accumulation of amyloid beta (Aβ), hyperphosphorylation...

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PMID: 29559905
DOI: 10.3389/fnagi.2018.00048

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