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Herpes simplex virus type 1 and Alzheimerâ€™s disease: increasing evidence for a major role of the virus

11 Aug 2014

Abstract excerpt

Herpes simplex virus type 1 (HSV1), when present in brain of carriers of the type 4 allele of the apolipoprotein E gene (APOE), has been implicated as a major factor in Alzheimer's disease (AD). It is proposed that virus is normally latent in many elderly brains but reactivates periodically (as in the peripheral nervous system) under certain conditions, for example stress, immunosuppression, and peripheral...

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PMID: 25157230
DOI: 10.3389/fnagi.2014.00202

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