Article

aiAtlas: High-Fidelity Cell Simulations of Genetic Perturbations in Rare Diseases and Cancers

2025-10-21

Abstract excerpt

<h4>Background</h4> Linking genetic perturbations to cellular phenotypes remains a central challenge in translational biology. Experimental iPSC and organoid models are powerful but constrained by scalability, variability, and difficulty modeling rare or polygenic states. <h4>Methods</h4> We developed aiAtlas v1.2 , a high-fidelity simulation platform that integrates Large Concept Model (LCM) logic with aiPSC-d...

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Literature Corpus work: bd682ff5-4daa-5ac0-8a5e-7fc12e0975d3
DOI: 10.1101/2025.10.20.683396

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