Article

Axonal TAU sorting requires the C-terminus of TAU but is independent of ANKG and TRIM46 enrichment at the AIS

2020-06-27

Abstract excerpt

Somatodendritic missorting of the axonal protein TAU is a hallmark of Alzheimer’s disease and related tauopathies. Cultured rodent primary neurons and iPSC-derived neurons are used for studying mechanisms of neuronal polarity, including TAU trafficking. However, these models are expensive, time-consuming and/or require the sacrification of animals. In this study, we evaluated four differentiation procedures to gen...

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Literature Corpus work: f66604d1-2003-51d0-8ad5-de6a8ef75881
DOI: 10.1101/2020.06.26.173526

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