Article

SH-SY5Y-derived neurons: A Human Neuronal Model System for Investigating TAU Sorting and Neuronal Subtype-Specific TAU Vulnerability

2020-12-23

Abstract excerpt

The microtubule-associated protein TAU is sorted into the axon in healthy brain neurons. Somatodendritic missorting of TAU is a pathological hallmark of many neurodegenerative diseases called tauopathies, including Alzheimer’s Disease (AD). Cause, consequence, and (patho)physiological mechanisms of TAU sorting and missorting are understudied, in part also due to the lack of readily available human neuronal m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 18081688-1e30-5120-ae1d-619f45b08691
DOI: 10.20944/preprints202006.0203.v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SH-SY5Y-derived neurons: A Human Neuronal Model System for Investigating TAU Sorting and Neuronal Subtype-Specific TAU VulnerabilityDOI 10.20944/preprints202006.0203.v2Read

Axonal TAU sorting requires the C-terminus of TAU but is independent of ANKG and TRIM46 enrichment at the AISSemantic proximity Read

Cultivation, differentiation, and lentiviral transduction of human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons for studying human TAUSemantic proximity Read

Axonal Tau sorting depends on the PRR2 domain and 0N4R-specific interactions hint at distinct roles of Tau isoforms in synaptic plasticitySemantic proximity Read

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.Semantic proximity Read

Tau depletion in human neurons mitigates Aβ-driven toxicitySemantic proximity Read

Neuron Cell DeathSemantic proximity Read

A Novel and Robust Protocol for Differentiation of SH-SY5Y Neuroblastoma Cells into Neuron Like CellsSemantic proximity Read

The TAU isoform 1N4R restores vulnerability of MAPT knockout human iPSC-derived neurons to Amyloid beta-induced neuronal dysfunctionSemantic proximity Read

Syntaxins 6 and 8 facilitate tau into secretory pathwaysSemantic proximity Read

Embryonic Stem Cell–Based Modeling of Tau Pathology in Human NeuronsSemantic proximity Read

The role of neuron-like cell lines and primary neuron cell models in unraveling the complexity of neurodegenerative diseases: a comprehensive reviewSemantic proximity Read

The Accumulation of Tau in Postsynaptic Structures: A Common Feature in Multiple Neurodegenerative Diseases?Semantic proximity Read