Article

Differential effects of human TAU isoforms: Somatic retention of 2N-TAU and increased microtubule number induced by 4R-TAU

2020-06-17

Abstract excerpt

In the adult human brain, six isoforms of the microtubule-associated protein TAU are expressed, which result from alternative splicing of exons 2, 3 and 10 of the MAPT gene. These isoforms differ in the number of N-terminal inserts (0N, 1N, 2N) and C-terminal repeat domains (3R or 4R) and are differentially expressed depending on the brain region and developmental stage. Although all TAU isoforms can aggregate an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a9fcf53f-a6fb-557a-a3c2-f590136eefbe
DOI: 10.1101/2020.06.16.154757

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential effects of human TAU isoforms: Somatic retention of 2N-TAU and increased microtubule number induced by 4R-TAUDOI 10.1101/2020.06.16.154757Read

Axonal Tau sorting depends on the PRR2 domain and 0N4R-specific interactions hint at distinct roles of Tau isoforms in synaptic plasticitySemantic proximity Read

The TAU isoform 1N4R restores vulnerability of MAPT knockout human iPSC-derived neurons to Amyloid beta-induced neuronal dysfunctionSemantic proximity Read

Differential effect of three‐repeat and four‐repeat tau on mitochondrial axonal transportSemantic proximity Read

Three- and Four-repeat Tau Regulate the Dynamic Instability of Two Distinct Microtubule Subpopulations in Qualitatively Different MannersSemantic proximity Read

Tau, microtubule dynamics, and axonal transport: New paradigms for neurodegenerative diseaseSemantic proximity Read

Structural and Functional Differences between 3-Repeat and 4-Repeat Tau IsoformsSemantic proximity Read

The six brain‐specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromesSemantic proximity Read

Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein.Semantic proximity Read

Modulation of Microtubule Dynamics by Tau in Living Cells: Implications for Development and NeurodegenerationSemantic proximity Read

FTDP-17 Mutations Alter the Aggregation and Microtubule Stabilization Propensity of Tau in an Isoform-Specific FashionSemantic proximity Read

[Dynamic neuropathology of tauopathy].Semantic proximity Read

The MAP1 family of microtubule-associated proteins.Semantic proximity Read