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Article

Axon outgrowth and neuronal differentiation defects after a-SMN and FL-SMN silencing in primary hippocampal cultures.

PloS one - 1 Jan 2018

Pletto Daniela, Capra Silvia, Finardi Adele, Colciaghi Francesca, Nobili Paola, Battaglia Giorgio Stefano, Locatelli Denise, Cagnoli Cinzia

Abstract excerpt

Spinal Muscular Atrophy (SMA) is a severe autosomal recessive disease characterized by selective motor neuron degeneration, caused by disruptions of the Survival of Motor Neuron 1 (Smn1) gene. The main product of SMN1 is the full-length SMN protein (FL-SMN), that plays an established role in mRNA splicing. FL-SMN is also involved in neurite outgrowth and axonal transport. A shorter SMN isoform, axonal-SMN or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29902268
DOI: 10.1371/journal.pone.0199105
PMCID: PMC6001960

Genes

SMN1

Provenance

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Axon outgrowth and neuronal differentiation defects after a-SMN and FL-SMN silencing in primary hippocampal cultures.PMID 29902268Read ↗

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