Article

Identification of molecular apocrine breast tumours by microarray analysis

2005-06-01

Abstract excerpt

There is compelling evidence from transgenic mouse studies and analysis of mutations in human carcinomas indicating that the TGF- signal transduction pathway is tumor suppressive. We have shown that overexpression of TGF-1 in mammary epithelial cells suppresses the development of carcinomas and that expression of a dominant negative type II TGF- receptor (DNIIR) in mammary epithelial cells under control of the MMT...

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Literature Corpus work: f64e8fb3-5721-59e4-ac37-8913f91ce40c
DOI: 10.1186/bcr1122

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