Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells.

Oncogene - 17 Apr 2008

Shafiei F, Rahnama F, Pawella L, Mitchell M D, Gluckman P D, Lobie P E

Abstract excerpt

Directed by microarray analyses, we report that autocrine human growth hormone (hGH) increased the mRNA and protein expression of DNA methyltransferase 1 (DNMT1), DNMT3A and DNMT3B in mammary carcinoma cells. Autocrine hGH stimulation of DNMT3A and DNMT3B expression was mediated by JAK2 and Src kinases, and treatment of mammary carcinoma cells with the DNMT inhibitor, 5'-aza-2'-deoxycytidine (AZA), abrogated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Autocrine Communication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferase 1

Share to DNA (Cytosine-5-)-Methyltransferases

Share to DNA Methyltransferase 3A

Share to DNA Methyltransferase 3B

Share to gamma Catenin

Share to Growth Hormone

Source

Identifiers

PMID: 17998942
DOI: 10.1038/sj.onc.1210917

Genes

DNMT1
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells.PMID 17998942Read ↗

Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone.Semantic proximity Read ↗

Oncogenic Transformation of Human Mammary Epithelial Cells by Autocrine Human Growth HormoneSemantic proximity Read ↗

Review of: Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormoneSemantic proximity Read ↗

Gene Expression Profiling to Identify Oncogenic Determinants of Autocrine Human Growth Hormone in Human Mammary CarcinomaSemantic proximity Read ↗

Epigenetic Regulation of Human Trophoblastic Cell Migration and InvasionSemantic proximity Read ↗

Plakoglobin Regulates the Expression of the Anti-apoptotic Protein BCL-2Semantic proximity Read ↗

Identification of molecular apocrine breast tumours by microarray analysisSemantic proximity Read ↗

Development of an Autocrine Neuregulin Signaling Loop with Malignant Transformation of Human Breast Epithelial CellsSemantic proximity Read ↗

Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor CellsSemantic proximity Read ↗

Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancerSemantic proximity Read ↗

Reactivation of SYK expression by inhibition of DNA methylation suppresses breast cancer cell invasiveness.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.