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Article

Metabolic phenotype and adipose and liver features in a high-fat Western diet-induced mouse model of obesity-linked NAFLD.

American journal of physiology. Endocrinology and metabolism - 15 Mar 2016

Luo Yuwen, Burrington Christine M, Graff Emily C, Zhang Jian, Judd Robert L, Suksaranjit Promporn, Kaewpoowat Quanhathai, Davenport Samantha K, O'Neill Ann Marie, Greene Michael W

Abstract excerpt

nonalcoholic fatty liver disease (NAFLD), an obesity and insulin resistance associated clinical condition - ranges from simple steatosis to nonalcoholic steatohepatitis. To model the human condition, a high-fat Western diet that includes liquid sugar consumption has been used in mice. Even though liver pathophysiology has been well characterized in the model, little is known about the metabolic phenotype (e.g.,...

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Identifiers

PMID: 26670487
DOI: 10.1152/ajpendo.00319.2015
PMCID: PMC4796265

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