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Article

Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target

26 Apr 2021

Abstract excerpt

OBJECTIVE: We evaluated the influence of sex on the pathophysiology of non-alcoholic fatty liver disease (NAFLD). We investigated diet-induced phenotypic responses to define sex-specific regulation between healthy liver and NAFLD to identify influential pathways in different preclinical murine models and their relevance in humans. DESIGN: Different models of diet-induced NAFLD (high-fat diet, choline-deficient...

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Diabetes, Cardiovascular Risks, and Lipoproteins
Liver Disease Diagnosis and Treatment
Peroxisome Proliferator-Activated Receptors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33903148
DOI: 10.1136/gutjnl-2020-323323

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