Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene knockout in cellular immunotherapy: Application and limitations

13 May 2022

Abstract excerpt

Cellular immunotherapy has achieved incremental success in recent years. Varieties of cell products are undergoing fundamental research and clinical trials, among which CAR-T cell therapy is approved for marketing. As research progresses, these cells need to be modified to promote their safety and efficacy. Gene-editing technologies have evolved from RNA interference (RNAi), including small interfering RNAs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35569695
DOI: 10.1016/j.canlet.2022.215736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene knockout in cellular immunotherapy: Application and limitationsPMID 35569695Read ↗

Progress and pitfalls of gene editing technology in CAR-T cell therapy: a state-of-the-art reviewSemantic proximity Read ↗

Unleashing the Therapeutic Potential of CAR-T Cell Therapy Using Gene-Editing Technologies.Semantic proximity Read ↗

Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cellsSemantic proximity Read ↗

Increasing Gene Editing Efficiency via CRISPR/Cas9- or Cas12a-Mediated Knock-In in Primary Human T CellsSemantic proximity Read ↗

Challenges of CRISPR-Based Gene Editing in Primary T CellsSemantic proximity Read ↗

Challenges and Opportunities of Gene Therapy in CancerSemantic proximity Read ↗

Leveraging CRISPR gene editing technology to optimize the efficacy, safety and accessibility of CAR T-cell therapySemantic proximity Read ↗

Challenges of CRISPR-based Gene Editing in Primary T CellsSemantic proximity Read ↗

Building Potent Chimeric Antigen Receptor T Cells With CRISPR Genome EditingSemantic proximity Read ↗

Using Gene Editing Approaches to Fine-Tune the Immune SystemSemantic proximity Read ↗

Boosting CAR-T cell therapy with CRISPR technologySemantic proximity Read ↗

Therapeutic potential of CRISPR/Cas9 gene editing in engineered T‐cell therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.