Article
Rapid evolution of enhanced Zika virus virulence during direct vertebrate transmission chains
2020-10-23
Abstract excerpt
Zika virus (ZIKV) has the unusual capacity to circumvent natural alternating mosquito-human transmission and be directly transmitted human-to-human via sexual and vertical routes. The impact of direct transmission on ZIKV evolution and adaptation to vertebrate hosts is unknown. Here we show that molecularly barcoded ZIKV rapidly adapted to a mammalian host during direct transmission chains in mice, coincident with...
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Identifiers and source
- Literature Corpus work
- f62573df-d138-5320-8a99-1adf8e355c50
- DOI
- 10.1101/2020.10.23.353003