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Article

Mapping the evolutionary landscape of Zika virus infection in immunocompromised mice

1 Jul 2020

Abstract excerpt

Abstract The fundamental basis of how arboviruses evolve in nature and what regulates the adaptive process remain unclear. To address this problem, we established a Zika virus (ZIKV) vector-borne transmission system in immunocompromised mice to study the evolutionary characteristics of ZIKV infection. Using this system, we defined factors that influence the evolutionary landscape of ZIKV infection and show that...

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PMID: 33408879
DOI: 10.1093/ve/veaa092

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