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From Depression-Associated Phospholipid Remodeling to Receptor-Active Lipid Signaling: The LPC-ATX-LPA Axis as a Testable Framework

2026-05-18

Abstract excerpt

Major depressive disorder (MDD) is increasingly understood as a disorder of integrated immune, endocrine, metabolic, neurovascular and synaptic regulation rather than a disease reducible to a single neurotransmitter deficit. Lipidomic studies have repeatedly identified glycerophospholipid abnormalities in MDD, but their mechanistic meaning remains unresolved because changes in bulk lipid abundance do not explain h...

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Literature Corpus work: f61bed09-2961-509a-be17-20b04875df5d
DOI: 10.20944/preprints202605.1120.v1

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