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Article

Peripheral Metabolic-Redox Signaling as a Core Mechanism of Major Depressive Disorder: Evidence From Deep Metabolomic Phenotyping

2025-12-17

Abstract excerpt

<h4>Background</h4> Major depressive disorder (MDD) is a neuro-immune, oxidative, and nitrosative stress (NIMETOX) disorder, in which peripheral immune-redox pathways intersect with metabolic networks leading to neurotoxicity within the limbic-prefrontal affective circuits. Comprehensive metabolomics analysis in well-phenotyped patients is vital to elucidate their metabolic profile. <h4>Objectives</h4> To identi...

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Literature Corpus work
2d31eedd-2907-5436-8cc8-0fa016f21017
DOI
10.64898/2025.12.15.25342323
Open publication

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Peripheral Metabolic-Redox Signaling as a Core Mechanism of Major Depressive Disorder: Evidence From Deep Metabolomic PhenotypingDOI 10.64898/2025.12.15.25342323
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