Mendelian Randomization Identifies Lipidomic Signatures of Depression Risk That Are Partly Reflected in Cortisol-Induced Membrane Remodeling and Modulated by St. John's Wort Extract (Ze 117).

Abstract excerpt

Major depressive disorder (MDD) is associated with altered membrane lipids, but the causal species remain uncertain. Using two-sample Mendelian randomization (MR) on lipidomic GWAS data and the latest MDD meta-analysis (~400,000 cases; 1.5 million controls), we identified 49 lipid species linked to MDD risk, notably enriched for phosphatidylcholines. Protective lipids were enriched for long-chain polyunsaturated...

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