Altered cortical synaptic lipid signaling leads to intermediate phenotypes of mental disorders.

doi:10.1038/s41380-024-02598-2

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Article

Altered cortical synaptic lipid signaling leads to intermediate phenotypes of mental disorders.

Molecular psychiatry - 1 Nov 2024

Tüscher Oliver, Muthuraman Muthuraman, Horstmann Johann-Philipp, Horta Guilherme, Radyushkin Konstantin, Baumgart Jan, Sigurdsson Torfi, Endle Heiko, Ji Haichao, Kuhnhäuser Prisca, Götz Jan, Kepser Lara-Jane, Lotze Martin, Grabe Hans J, Völzke Henry, Leehr Elisabeth J, Meinert Susanne, Opel Nils, Richers Sebastian, Stroh Albrecht, Daun Silvia, Tittgemeyer Marc, Uphaus Timo, Steffen Falk, Zipp Frauke, Groß Joachim, Groppa Sergiu, Dannlowski Udo, Nitsch Robert, Vogt Johannes

Abstract excerpt

Excitation/inhibition (E/I) balance plays important roles in mental disorders. Bioactive phospholipids like lysophosphatidic acid (LPA) are synthesized by the enzyme autotaxin (ATX) at cortical synapses and modulate glutamatergic transmission, and eventually alter E/I balance of cortical networks. Here, we analyzed functional consequences of altered E/I balance in 25 human subjects induced by genetic disruption...

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PMID: 38806692
DOI: 10.1038/s41380-024-02598-2
PMCID: PMC11541086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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