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Article

Peripheral metabolic-redox signaling as a core mechanism of major depressive disorder: evidence from deep metabolomic phenotyping.

Acta neuropsychiatrica - 24 Feb 2026

Maes Michael, Niu Mengqi, Maes Annabel, Luo Yiping, Yangyang Chenkai, Almulla Abbas F, Li Jing, Zhang Yingqian

Abstract excerpt

BACKGROUND: Major depressive disorder (MDD) is a neuro-immune, oxidative, and nitrosative stress (NIMETOX) disorder, in which peripheral immune-redox pathways intersect with metabolic networks leading to neurotoxicity within the limbic-prefrontal affective circuits. Comprehensive metabolomics analysis in well-phenotyped patients is vital to elucidate their metabolic profile. OBJECTIVES: To identify metabolic...

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PMID: 41731715
DOI: 10.1017/neu.2026.10065
PMCID: PMC13130358

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SI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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