Article
Metabolic Dysregulation of the Lysophospholipid/Autotaxin Axis in the Chromosome 9p21 Gene SNP rs10757274.
Circulation. Genomic and precision medicine - 1 Jun 2020
Meckelmann Sven W, Hawksworth Jade I, White Daniel, Andrews Robert, Rodrigues Patricia, O'Connor Anne, Alvarez-Jarreta Jorge, Tyrrell Victoria J, Hinz Christine, Zhou You, Williams Julie, Aldrovandi Maceler, Watkins William J, Engler Adam J, Lo Sardo Valentina, Slatter David A, Allen Stuart M, Acharya Jay, Mitchell Jacquie, Cooper Jackie, Aoki Junken, Kano Kuniyuki, Humphries Steve E, O'Donnell Valerie B
Abstract excerpt
BACKGROUND: Common chromosome 9p21 single nucleotide polymorphisms (SNPs) increase coronary heart disease risk, independent of traditional lipid risk factors. However, lipids comprise large numbers of structurally related molecules not measured in traditional risk measurements, and many have inflammatory bioactivities. Here, we applied lipidomic and genomic approaches to 3 model systems to characterize lipid...
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