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Article

Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2024

Neuffer Jeanne, Wagner Maude, Moreno Elisa, Le Grand Quentin, Mishra Aniket, Trégouët David-Alexandre, Leffondre Karen, Proust-Lima Cécile, Foubert-Samier Alexandra, Berr Claudine, Tzourio Christophe, Helmer Catherine, Debette Stéphanie, Samieri Cécilia

Abstract excerpt

INTRODUCTION: Evaluating whether genetic susceptibility modifies the impact of lifestyle-related factors on dementia is critical for prevention. METHODS: We studied 5170 participants from a French cohort of older persons free of dementia at baseline and followed for up to 17 years. The LIfestyle for BRAin health risk score (LIBRA) including 12 modifiable factors was constructed at baseline (higher score...

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Identifiers

PMID: 38775256
DOI: 10.1002/alz.13801
PMCID: PMC11180843

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