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Updated LIfestyle for BRAin health (LIBRA2) Score, Genetics, and Risk of Alzheimer Disease, Vascular Dementia, and Stroke in Older Adults.

Neurology - 25 Nov 2025

Rosenau Colin, Neuffer Jeanne, Köhler Sebastian, Helmer Catherine, Le Grand Quentin, Mishra Aniket, Debette Stéphanie, Trégouët David-Alexandre, Deckers Kay, Samieri Cécilia

Abstract excerpt

BACKGROUND AND OBJECTIVES: Dementia and stroke are major global causes of disability, with modifiable lifestyle factors playing a significant role in their development. The updated LIfestyle for BRAin health (LIBRA2) score integrates 15 modifiable risk and protective factors to quantify lifestyle-based dementia risk, but its relationship with stroke and dementia subtypes remains unexplored. We investigated...

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PMID: 41183252
DOI: 10.1212/WNL.0000000000214312
PMCID: PMC12590494

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APOE

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