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Enhanced Endocannabinoid Signaling Elevates Neuronal Excitability in Fragile X Syndrome

21 Apr 2010

Abstract excerpt

Fragile X syndrome (FXS) results from deficiency of fragile X mental retardation protein (FMRP). FXS is the most common heritable form of mental retardation, and is associated with the occurrence of seizures. Factors responsible for initiating FXS-related hyperexcitability are poorly understood. Many protein-synthesis-dependent functions of group I metabotropic glutamate receptors (Gp1 mGluRs) are exaggerated in...

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PMID: 20410124
DOI: 10.1523/jneurosci.0795-10.2010

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Enhanced Endocannabinoid Signaling Elevates Neuronal Excitability in Fragile X SyndromePMID 20410124Read ↗

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