Article

Relaxed constraint and functional divergence of the progesterone receptor (PGR) in the human stem-lineage

2019-10-09

Abstract excerpt

The steroid hormone progesterone, acting through the progesterone receptor (PR), a ligand-activated DNA-binding transcription factor, plays an essential role in regulating nearly every aspect of female reproductive biology. While many reproductive traits regulated by PR are conserved in mammals, Catarrhine primates evolved several derived traits including spontaneous decidualization, menstruation, and a divergent...

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Literature Corpus work: f600fc66-bd1d-5a15-a816-5217b34b9e96
DOI: 10.1101/799569

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