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Article

The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor.

Molecular phylogenetics and evolution - 1 May 2008

Chen Caoyi, Opazo Juan C, Erez Offer, Uddin Monica, Santolaya-Forgas Joaquin, Goodman Morris, Grossman Lawrence I, Romero Roberto, Wildman Derek E

Abstract excerpt

The gene encoding the progesterone receptor (PGR) acts as a transcription factor, and participates in the regulation of reproductive processes including menstruation, implantation, pregnancy maintenance, parturition, mammary development, and lactation. Unlike other mammals, primates do not exhibi...

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Source

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Identifiers

PMID: 18375150
DOI: 10.1016/j.ympev.2007.12.026
PMCID: PMC2713739

Genes

PGR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18375150-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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