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Article

Natural Selection Has Differentiated the Progesterone Receptor among Human Populations.

American journal of human genetics - 5 Jul 2018

Li Jingjing, Hong Xiumei, Mesiano Sam, Muglia Louis J, Wang Xiaobin, Snyder Michael, Stevenson David K, Shaw Gary M

Abstract excerpt

The progesterone receptor (PGR) plays a central role in maintaining pregnancy and is significantly associated with medical conditions such as preterm birth that affects 12.6% of all the births in U.S. PGR has been evolving rapidly since the common ancestor of human and chimpanzee, and we herein investigated evolutionary dynamics of PGR during recent human migration and population differentiation. Our study...

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Identifiers

PMID: 29937092
DOI: 10.1016/j.ajhg.2018.05.009
PMCID: PMC6035283

Genes

PGR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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