Article

Bulk and single-molecule analysis of a novel DNA2-like helicase-nuclease reveals a single-stranded DNA looping motor

2019-11-21

Abstract excerpt

<h4>ABSTRACT</h4> DNA2 is an essential enzyme involved in DNA replication and repair in eukaryotes. In a search for homologues of this protein, we identified and characterised Geobacillus stearothermophilus Bad, a novel bacterial DNA helicase-nuclease with similarity to human DNA2. We show that Bad contains an Fe-S cluster and identify four cysteine residues that are likely to co-ordinate the cluster by analogy...

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Literature Corpus work: f5d940ed-31b4-5647-9073-e1253b75a33b
DOI: 10.1101/851329

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