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Article

Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases.

Nucleic acids research - 10 Jan 2020

Zheng Li, Meng Yuan, Campbell Judith L, Shen Binghui

Abstract excerpt

DNA2 nuclease/helicase is a structure-specific nuclease, 5'-to-3' helicase, and DNA-dependent ATPase. It is involved in multiple DNA metabolic pathways, including Okazaki fragment maturation, replication of 'difficult-to-replicate' DNA regions, end resection, stalled replication fork processing, and mitochondrial genome maintenance. The participation of DNA2 in these different pathways is regulated by its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31754720
DOI: 10.1093/nar/gkz1101
PMCID: PMC6943134

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