Article
TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut.
Nature communications - 4 Dec 2017
Romagnani Andrea, Vettore Valentina, Rezzonico-Jost Tanja, Hampe Sarah, Rottoli Elsa, Nadolni Wiebke, Perotti Michela, Meier Melanie A, Hermanns Constanze, Geiger Sheila, Wennemuth Gunther, Recordati Camilla, Matsushita Masayuki, Muehlich Susanne, Proietti Michele, Chubanov Vladimir, Gudermann Thomas, Grassi Fabio, Zierler Susanna
Abstract excerpt
The melastatin-like transient-receptor-potential-7 protein (TRPM7), harbouring a cation channel and a serine/threonine kinase, has been implicated in thymopoiesis and cytokine expression. Here we show, by analysing TRPM7 kinase-dead mutant (Trpm7 R/R ) mice, that the enzymatic activity of the receptor is not essential for thymopoiesis, but is required for CD103 transcription and gut-homing of intra-epithelial...
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