Article

TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner

2024-12-07

Abstract excerpt

T lymphocyte activation is a crucial process in the regulation of innate and adaptive immune responses. The ion channel-kinase TRPM7 has previously been implicated in cellular Mg 2+ homeostasis, proliferation, and immune cell modulation. Here, we show that pharmacological and genetic silencing of TRPM7 leads to diminished human CD4 T-cell activation and proliferation following TCR mediated stimulation. In both pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9633531-34c2-5239-ab62-1b0fe5845053
DOI: 10.1101/2024.12.04.626765

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent mannerDOI 10.1101/2024.12.04.626765Read

TRPM7.Semantic proximity Read

Targeting ion channel TRPM7 promotes thymic development of Regulatory T cells by increasing IL-2-dependent STAT5 activationSemantic proximity Read

TRPM7: a unique channel involved in magnesium homeostasis.Semantic proximity Read

TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.Semantic proximity Read

TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut.Semantic proximity Read

Inactivation of TRPM7 kinase targets AKT signaling and cyclooxygenase-2 expression in human CML cellsSemantic proximity Read

Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.Semantic proximity Read

Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family.Semantic proximity Read

Molecular determinants of sensitivity and conductivity of human TRPM7 to Mg2+ and Ca2+.Semantic proximity Read

Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer.Semantic proximity Read

TRPM4.Semantic proximity Read

TRPM6.Semantic proximity Read