Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine.

doi:10.1124/pr.113.008268

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Article

Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine.

Pharmacological reviews - 1 Jul 2014

Nilius Bernd, Szallasi Arpad

Abstract excerpt

The large Trp gene family encodes transient receptor potential (TRP) proteins that form novel cation-selective ion channels. In mammals, 28 Trp channel genes have been identified. TRP proteins exhibit diverse permeation and gating properties and are involved in a plethora of physiologic functions with a strong impact on cellular sensing and signaling pathways. Indeed, mutations in human genes encoding TRP...

Topics

Animals
Drug Design
Humans
Molecular Targeted Therapy
Mutation
Signal Transduction
Transient Receptor Potential Channels

Source

Open in PubMed

Identifiers

PMID: 24951385
DOI: 10.1124/pr.113.008268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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