Article

Macrophage-specific NF-κB activation dynamics can segregate inflammatory bowel disease patients

2019-01-30

Abstract excerpt

The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation of the NF-κB transcription factor is a highly-regulated, dynamic event in IBD pathogenesis. We expressed the human NF-κB/p65 subunit in blood-derived macrophages, using lentivirus. Confocal imaging of p65 activation revealed that a higher proportion of macrophages from Crohn’s patients r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f5be6ff0-5f54-5766-96da-e61b2309b237
DOI: 10.1101/535096

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Macrophage-specific NF-κB activation dynamics can segregate inflammatory bowel disease patientsDOI 10.1101/535096Read

Lamina Propria Phagocyte Profiling Reveals Targetable Signaling Pathways in Refractory Inflammatory Bowel DiseaseSemantic proximity Read

Macrophages in Ulcerative Colitis: Immunomodulatory Roles, Phenotypic Switching, and Therapeutic Targeting.Semantic proximity Read

Pro-inflammatory secretome from intestinal epithelium recruits regulatory T cells for barrier defenceSemantic proximity Read

Identification and physiological significance of temporal NFκB signaling codewords deployed by macrophages to classify immune threatsSemantic proximity Read

LncRNAs Affecting NF-κB-Mediated Macrophage Inflammation Are Potential Therapeutic Targets in Human DiseasesSemantic proximity Read

Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells.Semantic proximity Read

The association between transcriptional regulation of macrophage differentiation and activation and genetic susceptibility to inflammatory bowel diseaseSemantic proximity Read

Truncating <i>RELA</i> variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kBSemantic proximity Read

Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohn’s disease associated adherent-invasive <i>Escherichia coli</i> infectionSemantic proximity Read

NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal IntegrationSemantic proximity Read

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.Semantic proximity Read

Development of a human primary gut-on-a-chip to model inflammatory processesSemantic proximity Read