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Article

Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells.

Frontiers in immunology - 1 Jan 2021

Somma Domenico, Kok Fatma O, Kerrigan David, Wells Christine A, Carmody Ruaidhrí J

Abstract excerpt

Since its discovery over 30 years ago the NF-ĸB family of transcription factors has gained the status of master regulator of the immune response. Much of what we understand of the role of NF-ĸB in immune development, homeostasis and inflammation comes from studies of mice null for specific NF-ĸB subunit encoding genes. The role of inflammation in diseases that affect a majority of individuals with health problems...

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Identifiers

PMID: 34721373
DOI: 10.3389/fimmu.2021.669906
PMCID: PMC8548695

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