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Article

Macrophages in Ulcerative Colitis: Immunomodulatory Roles, Phenotypic Switching, and Therapeutic Targeting.

Journal of innate immunity - 1 Jan 2026

Zhao Maojun, Yu Shaochen, Zhang Mengjie, Huang Yuting, Dou Ziyue, Tian Beibei, Yang Langlang, Lu Jian

Abstract excerpt

BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by dysregulated immune responses in the gut. Macrophages, as key innate immune cells in the intestinal mucosa, play a central role in both maintaining homeostasis and driving pathology in UC. SUMMARY: Under physiological conditions, intestinal macrophages exhibit a unique "inflammatory anergy" phenotype, supporting...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41528944
DOI: 10.1159/000550397
PMCID: PMC12923256

Genes

NLRP3
TNF

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