Article

UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repair

2024-05-03

Abstract excerpt

Mammalian Uracil DNA glycosylase (UNG) removes uracils and initiates high-fidelity base excision repair to maintain genomic stability. During B cell development, activation-induced cytidine deaminase (AID) creates uracils that UNG processes in an error-prone fashion to accomplish immunoglobulin (Ig) somatic hypermutation (SHM) or class switch recombination (CSR). The mechanism that governs high-fidelity versus mut...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f5b137b2-b7c8-5c73-8f44-8fe9775d0882
DOI: 10.1101/2024.04.30.591927

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repairDOI 10.1101/2024.04.30.591927Read

UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repair.Semantic proximity Read

UNG shapes the specificity of AID-induced somatic hypermutation.Semantic proximity Read

Error-free versus mutagenic processing of genomic uracil—Relevance to cancerSemantic proximity Read

Mutating for Good: DNA Damage Responses During Somatic HypermutationSemantic proximity Read

The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.Semantic proximity Read

Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Semantic proximity Read

Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils.Semantic proximity Read

Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated Lesions.Semantic proximity Read

Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase.Semantic proximity Read

Uracil–DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracilSemantic proximity Read

High-fidelity correction of genomic uracil by human mismatch repair activities.Semantic proximity Read

High-throughput analyses of a reconstituted diversity-generating retroelement identify intrinsic and extrinsic determinants of diversification.Semantic proximity Read