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Article

The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.

DNA repair - 1 Jun 2012

Torseth Kathrin, Doseth Berit, Hagen Lars, Olaisen Camilla, Liabakk Nina-Beate, Græsmann Heidi, Durandy Anne, Otterlei Marit, Krokan Hans E, Kavli Bodil, Slupphaug Geir

Abstract excerpt

In human cell nuclei, UNG2 is the major uracil-DNA glycosylase initiating DNA base excision repair of uracil. In activated B cells it has an additional role in facilitating mutagenic processing of AID-induced uracil at Ig loci and UNG-deficient patients develop hyper-IgM syndrome characterized by impaired class-switch recombination and disturbed somatic hypermutation. How UNG2 is recruited to either error-free or...

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Share to DNA Glycosylases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22521144
DOI: 10.1016/j.dnarep.2012.03.006

Genes

PCNA
UNG

Provenance

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Related research

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The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.PMID 22521144Read ↗

Uracil–DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracilSemantic proximity Read ↗

Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cellsSemantic proximity Read ↗

Error-free versus mutagenic processing of genomic uracil—Relevance to cancerSemantic proximity Read ↗

UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repairSemantic proximity Read ↗

UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repair.Semantic proximity Read ↗

FAM72A antagonizes UNG2 to promote mutagenic uracil repair during antibody maturationSemantic proximity Read ↗

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.Semantic proximity Read ↗

A role for PCNA ubiquitination in immunoglobulin hypermutation.Semantic proximity Read ↗

Investigation of N-Terminal Phospho-Regulation of Uracil DNA Glycosylase Using Protein Semisynthesis.Semantic proximity Read ↗

FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.Semantic proximity Read ↗

Genomic Uracil Homeostasis during Normal B Cell Maturation and Loss of This Balance during B Cell Cancer DevelopmentSemantic proximity Read ↗

A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reportedSemantic proximity Read ↗

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