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Article

UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repair.

Nucleic acids research - 5 May 2026

Mu Yunxiang, Chen Zaowen, Plummer Joshua B, Zelazowska Monika A, Dong Qiwen, Krug Laurie T, McBride Kevin M

Abstract excerpt

Mammalian uracil DNA glycosylase (UNG) removes uracils and initiates high-fidelity base excision repair to maintain genomic stability. During B cell development, activation-induced cytidine deaminase (AID) generates uracils in DNA, which UNG processes in an error-prone fashion to accomplish immunoglobulin (Ig) somatic hypermutation or class switch recombination (CSR). The mechanism that governs high-fidelity...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42137982
DOI: 10.1093/nar/gkag441
PMCID: PMC13176773

Genes

UNG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repair.PMID 42137982Read ↗

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Uracil–DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracilSemantic proximity Read ↗

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