Article

Mapping fibroblast plasticity across non-cancer lung diseases at single-cell resolution

2026-07-24

Abstract excerpt

Fibroblast plasticity underlies a wide spectrum of pulmonary diseases, yet the molecular programs governing fibroblast state transitions in non-malignant contexts remain poorly understood. We integrated 1,470,730 single-cell transcriptomes across three non-cancer lung diseases to construct a comprehensive fibroblast atlas. Integrated clustering and regulon analyses were used to delineate fibroblast subtypes, disea...

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Literature Corpus work: ac86061b-5577-5805-bd9f-65273bb41a77
DOI: 10.1186/s13073-026-01730-x

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