Article

The kinetic basis of CRISPR-Cas off-targeting rules

2017-05-30

Abstract excerpt

<h4>ABSTRACT</h4> Cas nucleases are popular tools for genome editing applications due to their ability to introduce DNA breaks at desired genomic locations. Such differential targeting is achieved through loading an RNA guide complimentary to the intended target sequence. As it turns out, sequences with only a partial match to the guide can also be cleaved. A large number of experiments have shed light on this of...

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Literature Corpus work: f575eac9-cd52-5319-9e61-1e682b0249b2
DOI: 10.1101/143602

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