Article

METTL7A and METTL7B are responsible for <i>S</i> -thiol methyl transferase activity in liver

2022-10-13

Abstract excerpt

S -Methylation of drugs containing thiol-moieties often alters their activity and results in detoxification. Historically, scientists attributed methylation of exogenous aliphatic and phenolic thiols to a putative S- adenosyl-L-methionine dependent membrane-associated phase II enzyme known as thiol methyltransferase (TMT). TMT has a broad substrate specificity and methylates the thiol metabolite of spironolactone...

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Literature Corpus work: f54f2aca-2cbd-518e-9700-25885bf5cd59
DOI: 10.1101/2022.10.12.511968

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