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Article

Post-translational stabilization of thiopurine S-methyltransferase by S-adenosyl-L-methionine reveals regulation of TPMT1 and 3C allozymes.

Biochemical pharmacology - 1 Apr 2012

Milek Miha, Smid Alenka, Tamm Riin, Kuzelicki Natasa Karas, Metspalu Andres, Mlinaric-Rascan Irena

Abstract excerpt

Thiopurine S-methyltransferase (TPMT; EC 2.1.1.67) plays a pivotal role in thiopurine treatment outcomes. However, little has been known about its intracellular regulation. Here, we describe the effect of fluctuations in physiological levels of S-adenosyl-L-methionine (SAM) and related metabolites on TPMT activity levels in cell lines and erythrocytes from healthy donors. We determined higher TPMT activity in...

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Identifiers

PMID: 22274639
DOI: 10.1016/j.bcp.2012.01.010

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Post-translational stabilization of thiopurine S-methyltransferase by S-adenosyl-L-methionine reveals regulation of TPMT*1 and *3C allozymes.PMID 22274639Read ↗

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