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Article

Insights into S-adenosyl-l-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms.

Mutation research. Reviews in mutation research - 1 Jan 2000

Li Jiaojiao, Sun Chunxiao, Cai Wenwen, Li Jing, Rosen Barry P, Chen Jian

Abstract excerpt

Enzymatic methylation catalyzed by methyltransferases has a significant impact on many human biochemical reactions. As the second most ubiquitous cofactor in humans, S-adenosyl-l-methionine (SAM or AdoMet) serves as a methyl donor for SAM-dependent methyltransferases (MTases), which transfer a methyl group to a nucleophilic acceptor such as O, As, N, S, or C as the byproduct. SAM-dependent methyltransferases can...

Topics

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Metabolism, Inborn Errors
Methyltransferases
Polymorphism, Single Nucleotide
S-Adenosylmethionine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34893161
DOI: 10.1016/j.mrrev.2021.108396
PMCID: PMC8847900

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