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Article

Sulfation of 4-hydroxy toremifene: individual variability, isoform specificity, and contribution to toremifene pharmacogenomics.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jun 2012

Edavana Vineetha Koroth, Dhakal Ishwori B, Yu Xinfeng, Williams Suzanne, Kadlubar Susan

Abstract excerpt

Toremifene (TOR) is a selective estrogen receptor modulator used in adjuvant therapy for breast cancer and in clinical trials for prostate cancer prevention. The chemical structure of TOR differs from that of tamoxifen (TAM) by the presence of a chlorine atom in the ethyl side chain, resulting in a more favorable toxicity spectrum with TOR. In addition, some patients who fail on TAM therapy benefit from high-dose...

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Identifiers

PMID: 22434874
DOI: 10.1124/dmd.111.044040
PMCID: PMC3362788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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