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Article

Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy.

The Journal of clinical investigation - 1 Mar 2004

Wheeler Matthew T, Allikian Michael J, Heydemann Ahlke, Hadhazy Michele, Zarnegar Sara, McNally Elizabeth M

Abstract excerpt

Vascular spasm is a poorly understood but critical biomedical process because it can acutely reduce blood supply and tissue oxygenation. Cardiomyopathy in mice lacking gamma-sarcoglycan or delta-sarcoglycan is characterized by focal damage. In the heart, sarcoglycan gene mutations produce regional defects in membrane permeability and focal degeneration, and it was hypothesized that vascular spasm was responsible...

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Identifiers

PMID: 14991064
DOI: 10.1172/JCI20410
PMCID: PMC351323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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