Article
Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells.
Human molecular genetics - 1 Aug 2003
Qian Qi, Hunter Larry W, Li Ming, Marin-Padilla Miguel, Prakash Y S, Somlo Stefan, Harris Peter C, Torres Vicente E, Sieck Gary C
Abstract excerpt
Autosomal-dominant polycystic kidney disease is a multiorgan disease and its vascular manifestations are common and life-threatening. Despite this, little is known about their pathogenesis. Somatic mutations to the normal PKD allele in cystic epithelia and cyst development associated with the unstable Pkd2(WS25) allele suggest a two-hit model of cystogenesis. However, it is unclear if this model can account for...
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