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Article

Neuroligin 3 R451C mutation alters electroencephalography spectral activity in an animal model of autism spectrum disorders.

Molecular brain - 7 Apr 2017

Liu Jackie J, Grace Kevin P, Horner Richard L, Cortez Miguel A, Shao Yiwen, Jia Zhengping

Abstract excerpt

Human studies demonstrate that sleep impairment is a concurrent comorbidity of autism spectrum disorders (ASD), but its etiology remains largely uncertain. One of the prominent theories of ASD suggests that an imbalance in synaptic excitation/inhibition may contribute to various aspects of ASD, including sleep impairments. Following the identification of Nlgn3R451C mutation in patients with ASD, its effects on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28385162
DOI: 10.1186/s13041-017-0290-2
PMCID: PMC5384041

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